Arc (for activity-regulated cytoskeleton-associated protein) is a growth factor and immediate early gene that is enriched in brain. Arc mRNA and protein levels are induced by neuronal activity, which is necessary to stimulate neuroplasticity, indicating a potential role for Arc in activity-dependent changes in dendrite function. Arc expression has been detected in neuronal cell bodies and dendrites in the hippocampus, amygdala, hypothalamus, striatum and cortex. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of ARC in Human lymphoma lysates using ARC antibody

Immunohistochemistry analysis of paraffin-embedded Human gastric cancer using ARC antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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