ARE-Luc荧光素酶报告基因质粒(ARE Luciferase Reporter Plasmid)

ARE Luciferase Reporter Plasmid（ARE-Luc荧光素酶报告基因质粒）

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ARE-Luc荧光素酶报告基因（报告基因质粒）（ARE luciferase reporter plasmid）是翌圣生物自主研发的用于检测ARE转录活性水平为目的的报告基因。ARE(antioxidant response element) 与Nrf2和NRF1转录因子结合，调节参与保护细胞免受氧化损伤的相关基因。

ARE报告基因主要应用于检测细胞的抗氧化水平或氧化应激状态、药物研究以及基因过表达和RNAi的表型分析等。

pGMARE-Lu是翊圣生物改造后的哺乳动物真核表达载体，在其多克隆位点插入了多个ARE结合位点，可以高灵敏度地检测ARE的激活水平。同时，对载体中预测出的其它转录因子以外的结合位点进行了适当的突变，增加了质粒的转录因子结合特异性。由于质粒体积减小，使得ARE报告基因更易于转染。

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冰袋运输。-20ºC保存，保质期1年。

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已发表文献

[ 1 ]Discovery of a novel Nrf2 activator that modulates mitochondrial function in neurons by regulating DHRS3-Nrf2 interaction after ischemic stroke

Journal:Theranostics|DOI:10.7150/thno.128602|IF:13.3

[ 2 ]Rosmarinic acid prevents refractory bacterial pneumonia through regulating Keap1/Nrf2-mediated autophagic pathway and mitochondrial oxidative stress

Journal:FREE RADICAL BIOLOGY AND MEDICINE|DOI:10.1016/j.freeradbiomed.2021.03.038|IF:7.38

[ 3 ]Let-7a inhibits Bcl-xl and YAP1 expression to induce apoptosis of trophoblast cells in early-onset severe preeclampsia

Journal:SCIENCE OF THE TOTAL ENVIRONMENT|DOI:10.1016/j.scitotenv.2020.139919|IF:6.55

[ 4 ]Negative pressure promotes macrophage M1 polarization after Mycobacterium tuberculosis infection via the lncRNA XIST/microRNA–125b–5p/A20/NF–κB axis

Journal:ANNALS OF THE NEW YORK ACADEMY OF SCIENCES|DOI:10.1111/nyas.14781|IF:6.5

[ 5 ]Salvianolate ameliorates renal tubular injury through the Keap1/Nrf2/ARE pathway in mouse kidney ischemia-reperfusion injury

Journal:JOURNAL OF ETHNOPHARMACOLOGY|DOI:10.1016/j.jep.2022.115331|IF:5.2

[ 6 ]NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4

Journal:CELLULAR ONCOLOGY|DOI:10.1007/s13402-026-01187-5|IF:4.8

[ 7 ]The New Synthetic H2S-Releasing SDSS Protects MC3T3-E1 Osteoblasts against H2O2-Induced Apoptosis by Suppressing Oxidative Stress, Inhibiting MAPKs, and Activating the PI3K/Akt Pathway

Journal:Frontiers in Pharmacology|DOI:10.3389/fphar.2017.00007|IF:4.4

[ 8 ]Rhizoma Paridis total saponins alleviate H2O2‑induced oxidative stress injury by upregulating the Nrf2 pathway

Journal:Molecular Medicine Reports|DOI:10.3892/mmr.2019.10827|IF:1.85

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