Integration of electrotaxis and durotaxis in cancer cells: Subtle nonlinear responses to electromechanical coupling cues
Lynn Htet Htet Aung, Xiatian Chen, Juan Carlos Cueva Jumbo, Zhe Li, Shao-ying Wang, Cheng Zhao, Ziqian Liu, Yin Wang, Peifeng Li
Journal：Molecular Therapy-Nucleic Acids
IF：8.89
DOI：10.1016/j.omtn.2021.08.006
PMID：34589283
Published：2021-08-19
research field：免疫学
Abstract
Results: Three ferroptosis-related-lncRNA signatures (AP000695.2, AL365181.3, and LINC01615) were identified, and then Kaplan–Meier, Cox regression analyses, and ROC curve confirmed that the ferroptosis-related-lncRNA model could predict the prognosis of STAD. The GSEA indicated that the three ferroptosis-related lncRNAs might be related to the extracellular matrix and cellular activities. LINC01615 is highly expressed in gastric cancer cell lines and tissues. A nuclear-cytoplasmic fractionation assay confirmed that in gastric cancer cell lines, most LINC01615 was enriched in the cytoplasm. Bioinformatics further predicts four potential target m"
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