In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implants
Taolei Wang, Chao Lin, Dan Batalu, Lu Zhang, Jingzhou Hu, Wei Lu
Journal:Journal of Magnesium and Alloys
IF:10.09
DOI:10.1016/j.jma.2020.12.014
PMID:
Published:2021-02-18
research field:分子生物学毒理学氧化应激与抗氧化信号通路药理学生殖医学
Abstract
PLLA-magnesium composites have been widely investigated as potential biodegradable materials for bone implants. Lower/higher corrosion resistance of the crystalized/amorphous magnesium alloys allows tailoring of biodegradability rate. In this work, the amorphous Mg 65 Zn 30 Ca 5 was investigated versus traditional crystalized Mg 65 Zn 30 Ca 5 , and a PLLA-Mg 65 Zn 30 Ca 5 composite has been successfully fabricated using hot injection process. Furthermore, the high corrosion resistance of the amorphous Mg 65 Zn 30 Ca 5 prevented the high alkalization and deterioration of mechanical strength. In addition, the high Zn content intended to improve the glass forming ability, also enhances the anti-bacterial property of the PLLA-Mg 65 Zn 30 Ca 5 composite. The remarkable performance of the PLLA-Mg 65 Zn 30 Ca 5 composite shows its promising application in bone repair and tissue regeneration.
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