分子生物学
IVD分子诊断
细胞培养与分析
蛋白研究
细胞因子
重组蛋白
抗体
高通量测序建库
病原检测UCF系列
生物医药
工具酶
抑制剂激活剂与常用试剂
仪器
耗材

In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implants

Taolei Wang, Chao Lin, Dan Batalu, Lu Zhang, Jingzhou Hu, Wei Lu

Journal:Journal of Magnesium and Alloys

IF:10.09

DOI:10.1016/j.jma.2020.12.014

PMID:

Published:2021-02-18

research field:分子生物学毒理学氧化应激与抗氧化信号通路药理学生殖医学

Abstract

PLLA-magnesium composites have been widely investigated as potential biodegradable materials for bone implants. Lower/higher corrosion resistance of the crystalized/amorphous magnesium alloys allows tailoring of biodegradability rate. In this work, the amorphous Mg 65 Zn 30 Ca 5 was investigated versus traditional crystalized Mg 65 Zn 30 Ca 5 , and a PLLA-Mg 65 Zn 30 Ca 5 composite has been successfully fabricated using hot injection process. Furthermore, the high corrosion resistance of the amorphous Mg 65 Zn 30 Ca 5 prevented the high alkalization and deterioration of mechanical strength. In addition, the high Zn content intended to improve the glass forming ability, also enhances the anti-bacterial property of the PLLA-Mg 65 Zn 30 Ca 5 composite. The remarkable performance of the PLLA-Mg 65 Zn 30 Ca 5 composite shows its promising application in bone repair and tissue regeneration.

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