PARP1 Suppresses the Transcription of PD-L1 by Poly(ADP-Ribosyl)ating STAT3
Ding Ling, Chen Xi, Xu Xiaqing, Qian Yuli, Liang Guikai, Yao Fengqi, Yao Zhangting, Wu Honghai, Zhang Jieqiong, He Qiaojun, Yang Bo
Journal：Cancer Immunology Research
IF：8.62
DOI：10.1158/2326-6066.CIR-18-0071
PMID：30401677
Published：2019-01-01
research field：肿瘤学免疫学
Abstract
PARP1-mediated poly(ADP-ribosyl)ation of STAT3 drives its dephosphorylation, leading to the inhibition of PD-L1 transcription across multiple cancer types. In patients, PARP1 and PD-L1 expression are inversely correlated. These data highlight a conserved regulatory mechanism for PD-L1 expression.
本文使用的Yeasen产品
相关产品
