PARP1通过Poly(ADP-Ribosyl)ating STAT3抑制PD-L1转录的免疫调控机制

PARP1 Suppresses the Transcription of PD-L1 by Poly(ADP-Ribosyl)ating STAT3

Ding Ling, Chen Xi, Xu Xiaqing, Qian Yuli, Liang Guikai, Yao Fengqi, Yao Zhangting, Wu Honghai, Zhang Jieqiong, He Qiaojun, Yang Bo

Journal：Cancer Immunology Research

IF：8.62

DOI：10.1158/2326-6066.CIR-18-0071

PMID：30401677

Published：2019-01-01

research field：肿瘤学免疫学

Abstract

PARP1-mediated poly(ADP-ribosyl)ation of STAT3 drives its dephosphorylation, leading to the inhibition of PD-L1 transcription across multiple cancer types. In patients, PARP1 and PD-L1 expression are inversely correlated. These data highlight a conserved regulatory mechanism for PD-L1 expression.

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