Structural Elucidation of Three 9,11-Seco Tetracyclic Triterpenoids Enables the Structural Revision of Euphorol J
Fang-Yu Yuan, Fan Xu, Run-Zhu Fan, Wei Li, Dong Huang, Gui-Hua Tang, Tao Yuan, Li-She Gan, Sheng Yin
Journal：JOURNAL OF ORGANIC CHEMISTRY
IF：4.35
DOI：10.1021/acs.joc.1c00631
PMID：34014670
Published：2021-05-20
research field：
Abstract
Compounds 1–3, the rare examples of 9,11-seco euphane or lanostane triterpenoids featuring an enol-hemiacetal functionality, were isolated from Euphorbia stracheyi. Their structures were elucidated by a combination of spectroscopic, computational, chemical, and single-crystal X-ray diffraction means, which enables the structure of previously published euphorol J to be revised as 1. 1–3 showed significant cytotoxicities on the breast cancer cell line MDA-MB-468 with IC50 values in the range of 2.9–3.9 μM.
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