Abstract

Real-time monitoring and accurate treatment are of great significance for reducing the side effects during the cancer therapy. In this work, we rationally prepared a smart nanoprobe based on core–shell terbium metal–organic gramework (MOF) with highly effective photothermal conversion capacity and drug release efficiency under near-infrared light irradiation for real-time fluorescence imaging-guided multimodal therapy. The nanoprobe can achieve prominent photothermal therapy and controllable drug release, act as a fluorescence thermometer, and also real-time feedback of temperature is expected to be achieved. At the same time, the two-photon ligand design significantly improves the tissue penetration ability of the nanoprobe. Our work is expected to provide a reference for precise treatment and real-time monitoring of tumors and at the same time provide new ideas for the formulation of individualized treatment plans.