Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury
He Hao, Yang Wu, Su Nan, Zhang Chuankai, Dai Jianing, Han Feng, Singhal Mahak, Bai Wenjuan, Zhu Xiaolan, Zhu Jing, Liu Zhen, Xia Wencheng, Liu Xiaoting, Zhang Chonghe, Jiang Kai, Huang Wenhui, Chen D
Journal：JOURNAL OF EXPERIMENTAL MEDICINE
IF：17.58
DOI：10.1084/jem.20211422
PMID：
Published：2022-11-09
research field：分子生物学药理学细胞生物学免疫学肺科学
Abstract
Using systemic EC–pericyte crosstalk analysis, this study identifies the NO–sGC as a key signaling that mediates EC–pericyte communication in the lung vasculature and demonstrates that pharmacological activation of the NO–sGC signaling promotes vascular integrity and mitigates inflammation-induced lung injury.
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