Abstract

Nanomaterials (NMs)-based cancer-targeted drug delivery systems have been promoted as a promising therapy. Using silk fibroin (SF), Ru(II)-modified selenium ( [email protected] ), Nivolumab (NMB), and heptapeptide (HP), we designed a pH-response innovative Nanomaterials for the drug delivery framework. The constructed [email protected] / [email protected] were nanospheres of ∼100 nm, contributing to enhanced permeability and retention (EPR) in tumor sites. The NMB was released from the pH-dependent nanocarriers, and in an acidic environment, the release of NMB was accelerated. [email protected] / [email protected] demonstrated improved cellular uptake and anticancer efficacy for hepatocellular carcinoma. In addition, the flow cytometry results demonstrated that [email protected] / [email protected] could efficiently destroy cancer cells. Further, histochemical investigations revealed that [email protected] / [email protected] exhibited less toxicity to the primary organs, suggesting that the constructed NMs are biocompatible in vivo. Overall, the findings imply that the nanomaterials-based delivery framework ( [email protected] / [email protected] ) is a novel treatment for hepatocellular carcinoma.