Coagulation factor (F)XI has been described as a component of the early phase of the contact pathway of blood coagulation, acting downstream of factor XII.In contrast to its mild hemostatic activities, FXI is known to play a significant role in thrombosis, as it is a demonstrated independent risk factor for deep vein thrombosis, ischemic stroke, and myocardial infarction. A better understanding of the varied and complex role of FXI in both thrombosis and hemostasis will help to allow better prediction of bleeding risk in FXI-deficient patients and also informing the development of targeted agents to inhibit the thrombotic activities of FXI while preserving hemostasis.

高纯度、高活性、低内毒素、高批间一致性

    SDS-PAGE

Human Coagulation factor XI on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

    SEC-HPLC

The purity of Human Coagulation factor XI is greater than 95% as determined by SEC-HPLC.

  ELISA

Immobilized Human Coagulation factor XI, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-Factor XI Antibody, hFc Tag with the EC50 of 5.4ng/ml determined by ELISA.

Bioactivity Data

Measured by its ability to cleave the fluorogenic peptide substrate, t-butyloxycarbonyl-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin (Boc-IEGR-AMC). The specific activity is >100 pmoles/min/μg.

-25 ~ -15℃保存，收到货之后有效期1年。
复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。