Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium是一种口服有效的糖皮质激素受体激动剂，其作为地塞米松的水溶性前体药物，在体内经酶解后发挥强效的抗炎和免疫抑制作用。
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英文别名 (English Synonym) |
Dexamethasone phosphate disodium |
|
中文名称 (Chinese Name) |
地塞米松磷酸二钠 |
|
靶点 (Target) |
Glucocorticoid Receptor |
|
通路 (Pathway) |
Endocrinology/Hormones |
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CAS号 (CAS NO.) |
2392-39-4 |
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分子式 (Formula) |
C22H28FNa2O8P |
|
分子量 (Molecular Weight) |
516.4 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于H2O |
-25~-15℃保存，有效期3年
[1] Bossa F, Annese V, Valvano MR, Latiano A, Martino G, Rossi L, Magnani M, Palmieri O, Serafini S, Damonte G, De Santo E, Andriulli A. Erythrocytes-mediated delivery of dexamethasone 21-phosphate in steroid-dependent ulcerative colitis: a randomized, double-blind Sham-controlled study. Inflamm Bowel Dis. 2013 Aug;19(9):1872-9. doi: 10.1097/MIB.0b013e3182874065. PMID: 23714676.
