伞形酮（7-羟基香豆素）是香豆素家族的一种天然口服活性荧光化合物。它具有显著的抗癌活性，可诱导HepG2细胞周期阻滞、凋亡和DNA片段化；同时表现出抗炎、抗氧化特性，能减轻过敏性气道炎症，并在慢性酒精摄入模型中发挥神经保护作用，且可透过血脑屏障。
|
英文别名 (English Synonym) |
Umbelliferone |
|
中文名称 (Chinese Name) |
7-羟基香豆素 |
|
靶点 (Target) |
Others |
|
通路 (Pathway) |
Natural Products |
|
CAS号 (CAS NO.) |
93-35-6 |
|
分子式 (Formula) |
C9H6O3 |
|
分子量 (Molecular Weight) |
162.14 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Yu SM, Hu DH, Zhang JJ. Umbelliferone exhibits anticancer activity via the induction of apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells. Mol Med Rep. 2015 Sep;12(3):3869-3873. doi: 10.3892/mmr.2015.3797. Epub 2015 May 18. PMID: 25997538.[2]Vasconcelos JF, Teixeira MM, Barbosa-Filho JM, Agra MF, Nunes XP, Giulietti AM, Ribeiro-Dos-Santos R, Soares MB. Effects of umbelliferone in a murine model of allergic airway inflammation. Eur J Pharmacol. 2009 May 1;609(1-3):126-31. doi: 10.1016/j.ejphar.2009.03.027. Epub 2009 Mar 14. PMID: 19289114.
