长春瑞滨（KW-2307碱基）是一种抗有丝分裂剂，能有效抑制HeLa细胞增殖，其IC50值为1.25 nM。
|
英文别名 (English Synonym) |
Vinorelbine |
|
中文名称 (Chinese Name) |
长春瑞宾 |
|
靶点 (Target) |
Microtubule Associated |
|
通路 (Pathway) |
Natural Products |
|
CAS号 (CAS NO.) |
71486-22-1 |
|
分子式 (Formula) |
C45H54N4O8 |
|
分子量 (Molecular Weight) |
778.93 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Liu XM, Jiang JD, Ferrari AC, Budman DR, Wang LG. Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells. Br J Cancer. 2003 Oct 20;89(8):1566-73. doi: 10.1038/sj.bjc.6601317. PMID: 14562033; PMCID: PMC2394338.[2]Poirier VJ, Burgess KE, Adams WM, Vail DM. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med. 2004 Jul-Aug;18(4):536-9. doi: 10.1892/0891-6640(2004)18<536:tdaeov>2.0.co;2. PMID: 15320594.
