ENMD-1199 (IRC-110160) 是2-methoxyestradiol的类似物，具有靶向微管、抗肿瘤、抗血管生成作用，在人体HCC细胞中，能够抑制HIF-1α和STAT3的活性。ENMD-1198抑制内皮细胞HMEC-1和BMH29L的增殖，其IC₅₀值分别为0.4 μM和3.8 μM。

参考文献

[1] Pasquier E, et al. ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties. Mol Cancer Ther. 2010 May;9(5):1408-18.

[2] Moser C, et al. ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma (HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer. 2008 Jul 23; 8:206.

[3] Snoeks TJ, et al. 2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo. Mol Cancer Ther. 2011 May;10(5):874-82.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。