The large envelope protein exists in two topological conformations, one which is termed external or Le-HBsAg and the other internal or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.

高纯度、高活性、低内毒素、高批间一致性

不要冷冻。2 ~ 8℃保存，收到货之后有效期1年。 打开后，无菌条件下，2 ~ 8℃保存，3个月有效期。