Recombinant Mouse IL-12/IL-23 p40 Monomer Protein_90472ES（90472ES）

Interleukin-12 (IL-12) is a heterodimeric cytokine composed of two disulfide-linked subunits, p35 and p40. It plays a crucial role in regulating immune responses, particularly in promoting the differentiation of T helper 1 (Th1) cells and enhancing the cytotoxic activity of natural killer (NK) cells. The p40 subunit is shared between IL-12 and IL-23, another important cytokine involved in immune regulation. In mice, IL-12 p40 is produced by various immune cells, including macrophages, dendritic cells, and B cells. The p40 subunit can also exist as a homodimer or monomer, which can act as an antagonist to IL-12.

The p40 subunit is a target for therapeutic interventions in autoimmune and inflammatory diseases. Monoclonal antibodies against IL-12 p40 have been developed to inhibit its activity and reduce inflammation. Also, IL-12 has potent antitumor activity by stimulating the immune system to attack cancer cells. Recombinant IL-12 or IL-12 vectors are being explored as potential cancer treatments.

高活性、高纯度、低内毒素、高稳定性

-25 ~ -15℃保存，收到货之日起有效期1年。复溶后，在4°C下可稳定保存1周。复溶后，-20℃~ -80℃下可稳定保存3-6个月。建议分装后于-20℃或-80℃冷冻保存以延长保质期。