生长分化因子15(GDF-15)是一种多肽激素,属于转化生长因子β(TGF-β)超家族。GDF-15在胎盘中高度表达,在肾脏、胰腺、前列腺和结肠中表达水平较低。与其他TGF-β家族蛋白类似,GDF-15被合成为一种大型前体蛋白,在二元切割位点(RXXR)被切割以释放羧基末端结构域。GDF-15在生理学和病理学方面具有广泛的生物学功能,特别是在衰老、癌症和代谢过程中。
高活性、高纯度、低内毒素、高批间一致性
SDS-PAGE

1 μg/lane protein was resolved with SDS-PAGE under non-reducing (NR) and reducing (R) conditions and visualized by Coomassie Blue staining.
Bioactivity

Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 osetoblast cells. The expected ED50 for this effect is less than 50ng/ml.
ELISA

Immobilized GDF-15 Protein, Mouse at 2.0μg/mL (100μL/well) can bind GFRAL Fc Chimera Protein, Human with EC50 of 11.85-19.23 ng/mL.
-25 ~ -15℃保存,收到货之后有效期1年。复溶后, 2 ~ 8 °C保存,7 天有效期。复溶后, -85 ~ -65℃保存,3个月有效期。建议首次使用时将蛋白等分,避免重复冻融循环。





