KIRA-7是咪唑并吡嗪类化合物，可结合IRE1α激酶（IC50=110nM）并以变构方式抑制其RNase活性，且具有抗纤维化作用。

[1] Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019 Jan 9;14(1):e0209824. doi: 10.1371/journal.pone.0209824. PMID: 30625178; PMCID: PMC6326459.