Ligandrol是一种口服有效的选择性雄激素受体激动剂，能够促进肌肉生长并保护骨骼结构。它通过增强蛋白质合成、抑制肌肉分解与氧化应激，改善肌肉细胞活力及骨组织微结构。该化合物还具有抗糖尿病、抗凋亡和抗氧化作用，可减轻 Cisplatin 诱导的肌肉毒性与细胞凋亡，并拮抗 Streptozotocin 对胰岛的损伤，从而改善 2 型糖尿病症状。

[1] Ustun Z, et al. Protective Effects of Ligandrol Against Cisplatin-Induced Mouse Muscle Cell Line Toxicity. Pharmaceutical Chemistry Journal, 2025: 1-11.[2]Sugumar D, Ghosh R, Rymbai E, Chandrasekaran J, Krishnamurthy PT, P RS, Sahu S, Selvaraj D. Ligandrol Ameliorates High-Fat Diet- and Streptozotocin-Induced Type 2 Diabetes Mellitus and Prevents Pancreatic Islets Degeneration. Assay Drug Dev Technol. 2024 Nov-Dec;22(8):397-408. doi: 10.1089/adt.2024.029. Epub 2024 Nov 6. PMID: 39501873.