用于精准调控的超声波-压电-热疗联合抗生素免用痤疮疗法的可溶微针内含姜黄素修饰纳米复合物

Abstract

The rational design of bioactive molecules to precisely engineer the energy-conversion interfaces represents an unexplored frontier in advanced therapeutics. Herein, we report a curcumin (Cur)-adapted nano-composites (BiO 2-X /Cur), integrated into a dissolvable microneedles (MNs) patch, for synergistic piezo-sono-thermal therapy against drug-resistant skin infections. The natural compound Cur is engineered not merely as an anti-inflammatory agent but as a critical molecular adapter that precisely tunes the interfacial charge dynamics and energy landscape at the composites interface, which extends carrier lifetime to 0.63 ns and significantly enhances oxygen adsorption capacity ( E ads = -1.821 eV). Under ultrasound irradiation, the patch demonstrates superior piezo-sonocatalytic activity (≈0.6 V piezoelectric output and d 33 value of −2.9 × 10 −12 C/N) to release reactive oxygen species and simultaneously delivers a substantial sono-thermal effect (ΔT > 20 °C). The dissolvable MNs platform ensures precise and painless intradermal delivery of BiO 2-X /Cur, enabling in vitro and in vivo near-complete eradication (>99.97%) of Propionibacterium acnes and methicillin-resistant Staphylococcus aureus , downregulating pro-inflammatory cytokines (IL-6, TNF-α, HIF-1α) while upregulating reparative markers (IL-10, Nrf2). This work establishes an emerging paradigm of using natural molecules as precision adapters for engineering high-performance composites, offering an intelligent and versatile platform for treating complex infectious diseases.