Three new C-glycosyflavones with acetyl substitutions from Swertia mileensis
Liu Xiaolong, Shi Yanhong, Hu Haijun, Li Jia, Li Chunge, Yang Li, Wang Zhengtao
Journal：Journal of Natural Medicines
IF：1.92
DOI：10.1007/s11418-018-1225-7
PMID：30051310
Published：2018-07-26
research field：天然产物化学遗传学与基因组学药用植物学生物化学
Abstract
Three new acetylated C -glycosylflavones, 3″,6″-di- O -acetylswertiajaponin ( 1 ), 4″,6″-di- O -acetylswertiajaponin ( 2 ), and 6″- O -acetylswertiajaponin ( 3 ), together with six known compounds were isolated from the whole herb of Swertia mileensis . Their structures were elucidated on extensive NMR experiments and mass spectrometry studies. 1 H and 13 C NMR data exhibited doublet signals at room temperature. Variable temperature 1 H NMR experiments were carried out to investigate the presence of rotational isomerism of C -glycosylflavones. All compounds showed potential antioxidant activities against apoptosis of H 2 O 2 -induced human embryo liver L02 cells.
本文使用的Yeasen产品
