Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation

Qian Yun, Wong Chi Chun, Xu Jiaying, Chen Huarong, Zhang Yanquan, Kang Wei, Wang Hua, Zhang Li, Li Weilin, Chu Eagle S.H., Go Minnie Y.Y., Chiu Philip W.Y., Ng Enders K.W., Chan Francis K.L., Sung Jo

Journal：CANCER RESEARCH

IF：9.12

DOI：10.1158/0008-5472.CAN-16-1595

PMID：28202509

Published：2017-04-15

research field：肿瘤学分子生物学癌症生物学

Abstract

This study defines a novel tumor suppressor gene in gastric cancer that functions in the unfolded protein response, an important stress response that limits cancer cell growth, with clinical implications as a survival biomarker in patients.

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