低聚半乳糖对肠道屏障的保护作用及其对肠道微生物群的调节功能
Galactooligosaccharides as a protective agent for intestinal barrier and its regulatory functions for intestinal microbiota
Geng Wang, Haidong Wang, Yuyue Jin, Zhiping Xiao, Muhammad Umar Yaqoob, Yueying Lin, Haohan Chen, Minqi Wang
Journal：FOOD RESEARCH INTERNATIONAL
IF：7.43
DOI：10.1016/j.foodres.2022.111003
PMID：35400418
Published：2022-02-22
research field：肿瘤学分子生物学基因治疗免疫治疗纳米医学
Abstract
Present study was conducted to comprehensively investigate the protective effects of galactooligosaccharides (GOS, 100%) against LPS-induced intestinal barrier damages, and the regulatory effect for intestinal microbes. Results showed that GOS intervention restored villi (jejunum and ileum) integrity, which were atrophic and broken in LPS-challenged mice. Electron microscopy, western blotting and immunofluorescence analysis exhibited that mice administrated with GOS showed higher expression of tight junction, which was confirmed in IPEC-J2 cells model. Meanwhile, the GOS increased the secretion of mucin and SIgA, as well as it alleviated inflammatory response caused by LPS in NF-κB dependent way. Administration of GOS could also increase the relative abundances of several specific friendly bacteria, and enhance the adaptability of intestinal microbiota. Collectively, these results indicated the potential of GOS for protecting intestine from injuries caused by stress as LPS challenge.
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