南美超级胎牛血清999尝鲜特惠
ChREBP转录调控PGC-1α促进小胶质细胞脂肪酸氧化减轻神经病理性疼痛
PGC‐1α Transcriptionally Regulated by ChREBP Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti‐Inflammatory Response
Ziwei Hu, Jiahui Pang, Xinli Liu, Yun Zhao, Yi Lu, Hui Chen, Hui Zeng, Youxin Yu, Yubai Zhao, Lijie Gao, Xuefei Zhang, Jian Jin, Kangling Wang, Yu Shi, Hongrui Zhan, Wen Wu
Journal：CNS Neuroscience & Therapeutics
IF：5
DOI：10.1002/cns.70744
PMID：41517974
Published：2026-01-10
research field：药理学进化生物学结构生物学骨科营养学遗传学与基因组学生物化学
Abstract
ChREBP transcriptionally regulates PGC‐1α, which enhances the expression of fatty acid oxidation genes, promotes the fatty acid oxidation process, and thereby increases the polarization of anti‐inflammatory microglia, reduces the level of inflammatory factors, and improves pain symptoms.
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