PGC‐1α Transcriptionally Regulated by ChREBP Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti‐Inflammatory Response
Ziwei Hu, Jiahui Pang, Xinli Liu, Yun Zhao, Yi Lu, Hui Chen, Hui Zeng, Youxin Yu, Yubai Zhao, Lijie Gao, Xuefei Zhang, Jian Jin, Kangling Wang, Yu Shi, Hongrui Zhan, Wen Wu
Journal：CNS Neuroscience & Therapeutics
IF：5
DOI：10.1002/cns.70744
PMID：41517974
Published：2026-01-10
research field：分子生物学植物遗传学细胞遗传学小麦育种
Abstract
ChREBP transcriptionally regulates PGC‐1α, which enhances the expression of fatty acid oxidation genes, promotes the fatty acid oxidation process, and thereby increases the polarization of anti‐inflammatory microglia, reduces the level of inflammatory factors, and improves pain symptoms.
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